Ever since The Big Bang Theory premiered, the show has had a lot of detractors. For example, Bert Kreischer insulted TBBT to Kaley Cuoco’s face, Joe Rogan was confused by its success, and he told Macaulay Culkin he was lucky he turned the sitcom down. However, The Big Bang Theory brought joy to millions of people. That is why fans care about Craig Ferguson’s unofficial cameo, Jim Parson’s favorite guest star, and the fact that Johnny Galecki once dated Sheldon’s mom on another show.
While those dedicated fans tend to know a lot about The Big Bang Theory, most don’t know the show once traumatized a former teen star. Similarly, most The Big Bang Theory fans are unaware that Mayim Bialik once suffered so much for one of the show’s most memorable scenes.
Mayim Bialik Did Something Gross To Get Through Kissing Jim Parsons During The Big Bang Theory
Now that the first season of Georgie & Mandy’s First Marriage is airing and has become a hit, that proves that fans can’t get enough of the franchise. Between the success of Georgie & Mandy’s First Marriage and Young Sheldon, millions of fans have grown to love the Cooper family more and more.
While fans can’t wait to see what happens on Georgie & Mandy’s First Marriage next, the success of that show is built on what came before it. As a result, Georgie & Mandy’s First Marriage fans should learn what they can about the original moments that created the ongoing interest in Sheldon’s family.
While Sheldon was always beloved by The Big Bang Theory fans, his relationship with Amy Farrah Fowler made him a much more humanized character. The fact that Sheldon was humanized like that played a pivotal role in the character spawning the two TBBT spin-offs. With that in mind, it is fascinating to learn that Mayim Bialik had to do something gross to cope with kissing Jim Parsons for a memorable The Big Bang Theory scene.
While Sheldon and Amy technically kissed for the first time during The Big Bang Theory’s 3rd season, there was nothing romantic about that moment. Instead, it wasn’t until a highly memorable episode of the show’s 7th season that the couple had their first real kiss.
Amy Farrah Fowler and Sheldon Cooper’s Most Romantic Moments, According to Screen Rant
- Their Iconic Valentine’s Day Kiss On the Train
- The First Time They Said “I Love You”
- When Sheldon Flew Across the Country to Propose
- Their Dream Wedding
- Makeups and Breakups Can Do Some Good
- When They First Moved In Together
- Coitus, Coitus, Coitus!
- They Achieved A Nobel Prize As a Unit
- Amy Was The First Woman To Meet Memaw
- When They Created A Cell Baby
As it turns out, Amy and Sheldon’s first real kiss was far from a dream for Mayim to film.

Related
This 2025 The Conners Episode Feels Like A Young Sheldon And The Big Bang Theory Crossover
The Conners had a storyline that feels like Young Sheldon and The Big Bang Theory crossover that fans of those shows need to see.
For fans who don’t remember, the memorable TV couple had their first real kiss after fighting with each other on Valentine’s Day.
Screen Rant Listed The Big Bang Theory’s Characters’ Age Ranges | |
---|---|
Character | TBBT Age Range |
Sheldon Cooper | 27-39 |
Leonard Hofstadter | 27-38 |
Penny | 21-33 |
Rajesh Koothrappali | 25-37 |
Howard Wolowitz | 25-37 |
Stuart Bloom | 34-45 |
Bernadette Rostenkowski-Wolowitz | 23-33 |
Amy Farrah Fowler | 30-39 |
An October 2022 Us Weekly article featured quotes from Jessica Radloff ‘s book, “The Big Bang Theory: The Definitive Inside Story of the Epic Hit Series.” One of the quotes from the book featured Mayim revealing that she rinsed her mouth out with peroxide between each take of Amy and Sheldon’s first kiss.
I rinsed with peroxide in between every kiss, every scene, every take, so that I wouldn’t get sick.
While that may seem like that remark was a slight at her longtime co-star, something that was going on with Jim at the time explained why Mayim was rinsing her mouth out.
As a part of Us Weekly’s article, they quoted Jim Parsons talking about what was going on behind the scenes during the filming of the memorable kiss.
In October 2022, Entertainment Weekly published an excerpt from “The Big Bang Theory: The Definitive, Inside Story of the Epic Hit Series.” That excerpt revealed that Jim Parsons felt very strongly that Mayim Bialik needed to remain a part of The Big Bang Theory’s starring cast. “I remember saying to Todd, ‘I will not let this character go without a fight.’ That was notable for me, only in that I almost never disagreed with the writers. But at some point I felt a certain way about working with Mayim that I was like, If for whatever reason we seemed to be weaning her off of this show as a character, I would go and talk to them.”
A video on YouTube features a clip of the episode that featured Amy and Sheldon’s first real kiss. If fans pay close attention to Jim’s voice in the clip as he portrays Sheldon, he sounds like he was sick at the time that scene was filmed. While talking to the author of “The Big Bang Theory: The Definitive Inside Story of the Epic Hit Series,” Jim revealed how sick he was while filming the kiss scene.
“I was sick with something, like a bad respiratory cold. And it was ironic because I always took care of myself, and here I am sick during one of the very rare times I have to kiss her. And kiss her several times because I knew we’d have to do several takes.”
While Jim referenced how sick he was while filming the scene, it was Mayim that really explained how ill her co-star was.

Related
A Saturday Night Live Star Had Their Career Threatened Before Parodying The Big Bang Theory’s Mayim Bialik
A Saturday Night Live star’s career was threatened if she didn’t do an impersonation of Mayim Biaik that upset the Big Bang Theory star.
While talking to Jessica for her definitive The Big Bang Theory book, Mayim claimed that Jim noticeably was suffering while filming their kissing scene.
The man was visibly sweating and feverish.
While it couldn’t have been enjoyable having to kiss someone over and over when they were so sick, at least Mayim was happy with the results. As she told the author of the book, she was happy with how the scene played out. Mayim also explained that while filming the scene was difficult, she successfully managed to avoid getting sick after kissing Jim over and over.
“It’s such a great scene, and it turned out so great, but it was a really hard night… To think of all the work that went into it, I’m so glad it was so sweet. I really loved it. Oh, and I did not get sick.”
Jim Parsons Felt Awful That Mayim Bialik Had To Kiss Him When He Was So Sick
After learning that Mayim Bialik rinsed her mouth out with peroxide over and over, it is easy to imagine how miserable that would be for her. However, fans shouldn’t forget how awful filming that scene would have been for Jim.

Related
Casting Penny From The Big Bang Theory Was So Hard That Several Actors Got Fired And Kaley Cuoco Was Initially Rejected
Casting Penny from The Big Bang Theory was a nightmare for the show’s producers since they kept hiring, firing, and rejecting actors.
According to Mayim, Jim was so sick that he was visibly sweaty while filming the scene. With that in mind, everyone should be able to relate to how miserable it would be to have to work when you feel that sick.
On top of that, not only did Jim have to deal with being that sick, he also clearly had to cope with guilt. After all, Us Weekly’s quotes from “The Big Bang Theory: The Definitive, Inside Story of the Epic Hit Series” included Jim talking how bad he felt that Mayim had to kiss him when he was so ill.
I was like, ‘This is unbelievable! I felt bad about it, I really did.’
Us Weekly’s article also quoted Jim from the book praising Mayim for still being willing to film the scene. “Mayim is always very game and never one to worry about those things too much.” Then, Jim remembered that Mayim was gargling between takes.
[Mayim] did have some sort of thing that she was gargling every time we did a take.
As unfortunate as it is that Jim was so sick, it certainly seems to have made filming that scene highly memorable for him and Mayim.

The Big Bang Theory
- Release Date
-
2007 – 2019-00-00
- Network
-
CBS
- Showrunner
-
Mark Cendrowski
- Directors
-
Mark Cendrowski
- Writers
-
Chuck Lorre, Bill Prady