Pregnancy Complications Increase Mortality Later In Life

(CTN News) – It has been found that pregnancy complications are associated with an increased mortality rate in later life, according to a study published online in Circulation on March 28.


According to a study conducted by Stefanie N. Hinkle, Ph.D., from the University of Pennsylvania in Philadelphia, and colleagues, pregnancy complications were associated with total and cause-specific mortality in 46,551 participants (45 percent African-American and 46 percent White).


According to the estimate, preterm delivery (PTD), hypertension in pregnancy, and gestational diabetes/impaired glucose tolerance (GDM/IGT) were associated with adjusted hazard ratios for underlying all-cause mortality and cause-specific mortality.

There was a median time of 52 years between the index pregnancy and death or censoring in the study.

It was found that mortality was higher among Black participants than it was among White participants (41 percent compared to 37 percent).

There were 15 participants, 5 participants, and 1 participant with PTD, hypertensive disorders of pregnancy, and gestational diabetes mellitus, respectively.

In the present study, it was found that the incidence of PTD was higher amongst Black participants than amongst White participants (20 versus 10 percent).

Among preterm spontaneous labor, preterm premature rupture of membranes, preterm induced labor, and preterm cesarean delivery versus full-term delivery, all-cause mortality was associated with preterm spontaneous labor, premature rupture of membranes, and preterm induced labor (adjusted hazard ratios, 1.07, 1.23, 1.31, and 2.09, respectively).

Pre-eclampsia and eclampsia, as well as superimposed preeclampsia and eclampsia compared with normotension (adjusted hazard ratios, 1.09, 1.14, and 1.32, respectively); as well as GDM/IGT compared with normoglycemia (adjusted hazard ratio, 1.14).

According to the adjusted hazard ratios, Black participants had a greater mortality risk as a result of preterm induced labor than White participants (adjusted hazard ratios, 1.64 versus 1.29).

Hinkle said in a statement that what makes these data valuable is that they provide more inclusive results, extending what was primarily limited to samples that were predominantly White to include Black pregnant women as well,” she added.


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